Quantitative Methods 2017

Indication protocol Head and neck cancer

Level of evidence after external validation

Endpoint

OARs

∆NTCP

Moderate-to severe xerostomia (patient-rated EORTC QLQ-HN35)

• Parotid gland contralateral

≥ 10% Level 3 → 2a

Dysphagia grade ≥ II (CTCAE)

• Superior PCM • Oral cavity • Superior PCM • Inferior PCM • Parotid gland contralateral • Esophageal inlet muscle

≥ 10% Level 3 → 2a

Tube feeding dependence

≥ 5% Level 3 → 2a