Radiobiology 2016

PROTON THERAPY: CLINICAL RESULTS

NUMBER OF PATIENTS of patients

D RBE Gy (RBE)

PRIMARY TUMOR

LOCAL CONTROL

REFERENCE

990 1922

99 % at 5 yr 96 % at 10 yr

Egger et al . (2001) Gragoudas et al . (2002) Liebsch, N., Personal communication (2005)

Uveal melanoma

70 in 5 Fx

Skull base chondrosarcoma

~ 69

202

95 % at 10 years

Chordoma

~ 69

132

59 % / 44 % at 5 / 10 yr

Terahara et al . (1999)

Prostate TIII - TIV (photons ± proton boost)

67.2 vs. 75.6 (Phase III trial)

202

80 % vs. 92 % at 5 yr 60 % vs. 77 % at 8 yr 75 % / 73 % biochemical disease-free survival at 5 / 8 yr

Shipley et al . (1995)

Prostate TIa - TII

74

1255

Slater et al . (2004)

Prostate TI - TII (photons ± proton boost)

70.2 vs. 79.2

393

61.4% vs. 80.4% at 5 yr Zietman et al . (2005)

Non-small cell lung cancer. Stage I

73.8

27

86% at 2 yr

Bush et al . (2004a)

72 (16 Fx in 29 days) 63 (15 Fx in 3 weeks)

162 34

87 % at 5 yr 75% at 2 yr

Chiba et al . (2005) Bush et al . (2004b)

Hepatic cancer

34 % / 18 % survival at 2 / 3 yr

Glioblastoma multiforme 90 BID in 5 weeks 23

Fitzek et al . (1999)

Adenocystic carcinoma of the paranasal sinus

23

93% at 5 years

Pommier et al . (2005)

76  surgery

Axial skeleton: Chondrosarcoma Chordoma

72.2 74.6

6 14

100% at 5 yr 53% at 5 yr

Hug et al . (1995)

ESTRO 2015