Radiobiology 2016
Segment of mouse intestine irradiated with varying doses
XRT
a
b
c d
12.5Gy
14.0Gy
15.5Gy
17.0Gy
Day 13 Overt tissue response (e.g. ulceration) is dose-dependent with a threshold followed by a rapid increase in severity. a. Patchy breakdown of mucosa except in shielded mucosa at top of specimen. b. Ulcerated mucosa being resurfaced by near-confluent nodules regenerated from a large number of independently surviving jejunal clonogens. c. Severe ulceration but with about 60 discrete clonogen-derived mucosal nodules. d. As for c. but only 4 regenerated nodules.
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