Radiobiology 2016

1/03/2016

Target volume includes normal tissue • Microscopic tumor infiltration in surrounding normal tissue • Normal tissues within tumor (soft tissue, blood vessels) • Normal structures in entrance and exit dose of the radiation beam Side-effects cannot, a priori, be considered a consequence of incorrect treatment

3

Why assess adverse effects?

• To assess the therapeutic ratio • eg change in treatment strategy

Probability of Tumor Control

1

Probability of Normal Tissue Damage

Therapeutic Effect (A)

Max. Tolerance

Response probability

0

A

Dose (Gy)

4

2