Radiobiology 2016

1/03/2016

Small bowel toxicity

• Late toxicity • Mucosal atrophy • Vascular sclerosis • Focal ischemia, fibrosis, edema, serosal thickening • Malabsorption, dysmotility • Intestinal obstruction, fistula • Presents clinically 6 months to 3 years after radiation • May lead to: • Complications requiring surgery • Parenteral nutrition • Prognosis is poor

Small bowel toxicity • Radiation enteritis: oedema, hyperemia, stiffness

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