Radiobiology 2016

1/03/2016

Scoring of side-effects: key points

• Use a published system • Minimize the number of variables • Use forms easy to read • Define endpoints • Test inter-observer variability • Document observations (e.g. pictures) • Record

• Baseline morbidity • Invasive procedures • Comorbidity • Other relevant treatments

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Take home messages • Normal tissue side effects are mandatory to score • Therapeutic ratio • Quality assurance (QA) • Both early and late reactions may develop in the same organ • Use validated scoring systems to record normal tissue effects • Score before, during and after RT! • Extend follow-up to several years after RT to get knowledge on late morbidity 50

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