Radiobiology 2016

DNA Repair and Cancer 1. Most anticancer agents work by damaging DNA 2. Changes in DNA repair influence radiosensitivity

1

1

0.1

0.1

0.01

0.01

Human fibroblasts

Surviving fraction

Surviving fraction

Human tumor cells

0.001

0.001

0

2

4

6

8

10

12

0

2

4

6

8

10

12

Dose (Gy)

Dose (Gy)