Radiobiology 2016

2 Distinct G2 checkpoints induced by IR

Early – Dose independent (1-10Gy) – Applies to cells irradiated in G2 – ATM dependent – Does not affect radiosensitivity

Late

– Dose dependent – Applies to cells irradiated in G1 or S-phase – “ classical ” G2 delay – ATR dependent – May affect radiosensitivity

SLOW