Radiobiology 2016

cells at intermediate hypoxia levels may determine the response of fractionated irradiation

10 0

-1

10

-2

10

-3

10

-4

10

10% hypoxic cells with full reoxygenation (diffusion)

-5

10

-6

10

-7

10

Surviving Fraction

10% hypoxic cells with full reoxygenation (binary)

-8

10

No Hypoxic Cells

-9

10

0 10 20 30 40 50 60 -10 Total Dose (2 Gy Fractions)

10

Wouters and Brown,1997