Radiobiology 2016
HIF and cancer
• Loss of VHL causes overexpression of HIF and renal cell carcinoma
• HIF is overexpressed in many cancers
– Mimics hypoxia biology in normoxia
Made with FlippingBook
HIF and cancer
• Loss of VHL causes overexpression of HIF and renal cell carcinoma
• HIF is overexpressed in many cancers
– Mimics hypoxia biology in normoxia
Made with FlippingBook