Radiobiology 2016
ARCON A ccelerated R adiotherapy + C arbOgen + N icotinamide
Tumor cell proliferation
Chronic hypoxia
Acute hypoxia
S
S
D
S
S
D
S S
D
D
D
S
S S
S
S
S D S
S S S
S
D
S
S
D
D
S
S
S
D
S
S
S
D
S
S
S
S
S
D
D D D
S S S
S
S
S
S
S
S S
D
D
S
S
S
S S S S
D S
S
D
S
S
D
S
S
S
S
D
S
D D
D
S
D
S
D
S
S
S
S S
S
S
S
D
S
D
S
S S
D
S
S
S S
D
D
D D
S
D
D
D
S
S
S
D D
S S
D
D
S
D
S
S
D
S
S
S
S
S
D D
S
S S
D
S
D
S
S
S
D
S
S
S
S
S
S
D
S
D
D
S S S
D
D
S
S
S
D
D
S
S
S
S S S
D
S
S
S
D
S
S S S
D
S
S
D D
D
S
D
S
S
S
D
D
D D
S
S S
S
S
S
S
S
D
S
D D
D
S S
S
Carbogen
D D
D
Nicotinamide
98% O
+ 2% CO 2
2
Accelerated fractionation
S
S
D
S
S S S S S S D
D
S S
D
D
S
S
S D S
S S S
S
D
S
S
D
D
S
D
S
S
S
D
S
S
S
S
S
stem cell differentiated cell
S
D
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