Radiobiology 2016

RTOG 90-03: A Phase III Trial Assessing Relative Efficacy of Altered Fractionations

R A N D O M I

Stage III & IV SCC of :

1. Conventional Fractionation: 70 Gy / 35 F / 7 W

• Oral cavity • Oropharynx • Larynx • Hypopharynx

2. Hyperfractionation:

81.6 Gy / 68 F / 7 W (1.2 Gy/F)

3. Accelerated Fractionation (Split): 67.2 Gy / 42 F / 6 W (2 W Rest)

Stratify : • No vs N+ • KPS

4. Accelerated Fractionation (CB):

Z E

72 Gy / 42 F / 6 W (1.8-1.5 Gy/F)

60-80 VS 90-100

ESTRO