Radiobiology 2016

1/03/2016

Pitfalls • Problems with clinical data! • Extremely heterogeneous populations • Curative and palliative intent in the same series • Changes in staging and radiotherapy techniques • Changes in normal tissue scoring Experimental animal systems have been essential to understand the radiobiology of retreatment tolerance

25

Head & neck

• Review post-op RT for recurrent HNSCC • Major late complications are fibrosis, mucosal ulceration/necrosis and osteoradionecrosis • Nevertheless, high- dose re-irradiation recommended

Kasperts Oral Oncol 2005

26

13