Radiobiology 2016

1/03/2016

Prostate • Brachytherapy is a feasible salvage option for pts with local recurrences after initial RT for prostate cancer

Prospective studies needed to better define efficacy and toxicity

35

Ramey World J Urol 2013

Prostate

• Toxicity fairly high

Ramey World J Urol 2013 ED (%) Fistula

Treatment Modality,dose a

Number of patients

Study

GU Grade 1–2

GU Grade 3–4

GI Grade 1–2

GI Grade 3–4

Incontinence (%)

formation (%)

(%)

(%)

(%)

(%)

Butler et al. [35]; 30 Teh et al. [31]

Au 198 , 20 Gy

A-37 L-7

0

A-13 L-3

0

NR

NR

NR

Wong et al. [34]

17

I 125 , 127-139 Gy Pd 103 , 119 Gy

53

47

65

6

18 b

NR

0

Nguyen et al. [30] 25 Lee et al. [26] 21 Allen et al. [18] 12 Lee et al. 27 21 Tharp et al. [32] 7 Aaronson et al. [17] 24 Burri et al. [20] 37

I 125 , 137 Gy HDR, 36 Gy/6 fractions I 125 /Pd 103 , 90–112.5 Gy Pd 103 , 90 Gy HDR, 6-9 Gy/2-6 fractions ? 71 NR 86 42 29

20 14

NR 14

20 0 0 0 0

12 0 25 NR 29

NR 92 NR NR 100 NR 75

13 0

0 0 0 8

0 5 8 5

0 0 0 0 3

29 c

14

I 125 /Pd 103 , 72 Gy Pd 103 , 110 Gy I 125 , 135 Gy

33 32

4 3

4 5

Moman et al. [29] 31

I 125 , 145 Gy

A-87 L-55 ‘Low’

A-3 L-19

A-55 L-51

A-0 L-6

NR

NR

6

Jo et al. [24]

11

HDR, 22 Gy/2 fractions

0

0

0

0

NR

0

36

18