Radiobiology 2016

1/03/2016

Summary clinical data • Re-irradiation is an option for patients with recurrent or second tumors • Risk of normal tissue damage and impact on quality of life must be taken into account

Take home messages • If tolerance has already been exceeded: no re- irradiation possible without loss of function • Early effects • Low to moderate doses: • Restitution of original tolerance may be complete after tissue- specific and dose-dependent time intervals • High doses: • Residual damage may remain for longer intervals, particular at the stem cell level, which is not necessarily reflected in functional tissue compartments 40

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