Radiobiology 2016

Tumor hypoxia

N

NO

18 F-MISO

2

N

18 F-AZA

HO

OH

N

N

O

18 F

CH

2

NO

18 F

2

HO

diffusion

tumour cell

nitroreductases e -

e -

Protein, RNA

18 F-MISO - , 18 F-AZA -

18 F-MISO, 18 F-AZA

-

O

O

oxidation

2

2

ESTRO