Radiobiology 2016

Dose-painting: randomized phase- II study design

PET signal intensity

PTV 70 Gy

PTV 70 Gy

CTV 70 Gy

CTV 70 Gy

70 70 70 70

75 80 70 86

high

70 70 70 70

86 70 80 70

70 70 70 70

70 75 70 75

70 70 70 70

80 70 86 80

low

Standard arm Median GTV dose: 70 Gy

Experimental arm A: PET-based dose increase Median GTV dose: 75 Gy

ESTRO