Radiobiology 2016

Radiobiological mechanisms underlying the dose rate effect

Time to give 2 Gy

100 h

10 h

1 h

10 min

1min

Repopulation

Reoxygenation

Redistribution

Repair

Modified from Steel et al (1986)

HDR

LDR MDR

0.01

0.1

1

10

100

1000

Dose rate (cGy/min)