Radiobiology 2016

1/03/2016

Experimental studies Late effects

17

Skin • Late radiation effects – mouse hind-limb

7 hind limb deformation

Two 10-fraction courses separated by 6 months Effect of re-irradiation more pronounced after more aggressive initial treatment Poorer retreatment tolerance than for early skin reactions

post 10 × 5 Gy

Severity (arbitrary units) 0 1 2 3 4 5 6

post 10 × 4 Gy

treatment alone

Brown & Probert Radiol 1975

3

4

5

6

7

Reirradiation dose per fraction (Gy)

18

9