Radiobiology 2016

1/03/2016

Urinary bladder • Retreatment tolerance mouse bladder

20

No recovery between 1 day and 9 months after initial treatment Progression of (subclinical) damage results in shortening of latent times after retreatment Extreme caution when re-irradiating urinary bladder!

Stewart Int J Radiat Oncol Biol Phys 1990

15

2F / 9 mo

10

2F / 1 d

micturition frequency 0 5

2F / 3 mo

0

5

10 15 20 25 30 35

total dose (Gy)

21

Summary experimental data

Modified from Stewart FA & van der Kogel AJ Semin Radiat Oncol 1994

100 120

20 40 60 80

Reirradiation dose (% of EQD tol ) skin/oral mucosa

lung pneumonitis

20 40 60 80 100 0

early effects

kidney (bladder) (heart?)

late effects

spinal cord

0 20 40 60 80 100 0

0 20 40 60 80 100 120

Initial dose (% of EQD tol )

11