Radiobiology 2016

1/03/2016

Head & neck

115 patients reirradiation + various CT Initial treatment median 68 Gy Retreatment median 65 Gy

Salama Int J Radiat Oncol Biol Phys 2006

29

Head & neck • Head & neck reirradiation: selection criteria • Patient related considerations • No severe sequelae of previous radiation treatment • No significant comorbidities • PET-CT is suggested for staging

• Interval between RT courses: at least 6 months, preferably longer (1y) • Better prognosis: • Previous surgery • Small (<30cm³) tumor size; caution with bulky tumors (>60cm³) • True second primary tumors (as compared to recurrences) • Tumors in nasopharynx and larynx • EGFR expression/HPV status: uncertain (needs to be evaluated in the context of re-irradiation)

Cacicedo Cancer Treatment Reviews 2014

30

15