Radiobiology 2016

Tumor Models

• Syngeneic mouse models • Tumor models derived from spontaneous tumors in mice • Usually non-immunogenic • Can be transplanted to other syngeneic mice • Xenografts • Human tumors grown in immunodeficient mice: Nu/Nu (nude mice), SCID Orthotopic models Subcutaneously - patient-derived cell lines - patient-derived organoids - patient-derived xenografts • Tumors arising in genetically modified mice • Transgene, knockout, knock-in, etc.