Radiobiology 2016

summary: tumor growth delay • dependent on reliable volume measurement (difficult!) with ultrasound imaging or bioluminescence more reliable than manual caliper • only suitable for few logs of tumor cells (selection) • reflects growth rate of clonogenic and non-clonogenic cells • dependent on growth rate of tumor - comparison of different tumors difficult - drugs may change growth rate (overestimation of efficacy) - radiation damage of vessels changes growth rate (tumor bed effect; overestimation of efficacy)