Radiobiology 2016

1/03/2016

How to measure normal tissue response? • Scoring of gross tissue effects • Scoring systems: grade the severity of tissue damage using an arbitrary scale • Assays of tissue function • Functional assays to measure radiation effects • E.g. blood counts as an indicator of bone marrow function • Clonogenic assays (L1.4) • Methods by which colony of cells that derive from a single irradiated cell can be observed

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Scoring of side-effects: frequency • Two aspects must be considered for documentation • Frequency • Early reactions can undergo considerable changes in clinical manifestation in short periods • Scoring at weekly basis: during and for some weeks after RT • Late reactions develop slowly and are usually irreversible • Scoring at intervals of several months after the end of RT (dynamics) • At later time points at annual intervals

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