Radiobiology 2016

Potential loss of effect in IMRT: Prostate PC-3 cell survival in vitro (Joiner et al, Wayne State University, Detroit)

0.59

2 Gy in 6 “fields”

0.58

0.57

Loss in effective dose: Acute to 60 min: 9% 5 min to 45 min: 6% 5 min to 30 min: 4%

0.56

Surviving Fraction

0.55

 /  = 7.6 Gy t 1/2

= 24.5 min

0.54

0

10

20

30

40

50

60

Time (min)