Research Masterclass in Radiotherapy Physics 2017
Building evidence for RT
4D
R&D – engineering phase, phantom studies, dosimetry in anthropomorphic phantoms
Pre-clinical
INCREASING EVIDENCE
Clinical implementation, QA, process and dosimetry measures, define use of technology
Phase 0
Systematic application in an expanded cohort of consecutive pts, toxicity and efficacy endpoints Bio-effect modeling to estimate clinical relevance of quality improvement WITH 95% CI
Phase I/II
Phase IIIR or Phase IIINR
Controlled clinical trial – randomized if possible or opt-in on institutional basis, toxicity & efficacy
Post-marketing recording of outcomes, generalizability of results when rolled out in the community
Phase IV
Courtesy of S. Bentzen
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