Research Masterclass in Radiotherapy Physics 2017
24
Normal Tissue Sparing: Piglet cerebellum
Normal tissue sparing
300 Gy
Piglet cerebellum 15 months post ir.
- Cell death and damages observed only along the microbeam paths - No damage in between microbeams - No macroscopic tissular necrosis observed as in conventional therapy
Hyp: no necrosis ↔ no damage on normal brain vasculature
Laissue et al. Proceedings of SPIE . 4508. 2003 Dilmanian et al. Neuro-oncol . 2002. Vol 4. p. 26-38 Slatkin DN et al. Med Phys . 1992. Vol 19. p. 1395-400
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