Research Masterclass in Radiotherapy Physics 2017

Modelling normal tissues response: a long successful story

 Assessment and modeling of dose-volume effects  Quantitative (organ-based) relationships  NTCP models through DVH reduction (LKB, gEUD….)  Mechanistic models  Impact of fractionation (LQ-based and updates…)  Milestones of Emami/Burman paper (1991) and QUANTEC Supplement (2009)   n i n/1 i i D*v EUD       V eff V whole  

n ≈ volume effect

D max

EUD