Research Masterclass in Radiotherapy Physics 2017

Modelling normal tissues response: a long successful story

 Assessment and modeling of dose-volume effects  Quantitative (organ-based) relationships  NTCP models through DVH reduction (LKB, gEUD….)  Impact of fractionation (LQ-based and updates…)  Milestones of Emami/Burman paper (1991) and QUANTEC Supplement (2009)  Quantitative analyses dealing with the relationship between dosimetric data (for instance DVH) and toxicities are heavily present in our Journals and their scientific impact is high…..!  Considering all papers published in the last 10 years in the Green or Red Journal (n=10.500), 3/20, 8/50 and 12/100 most cited papers come from the field of quantitative modelling of toxicity

n

i     

  

V eff V whole

 

n/1

EUD

D*v

i

i

………from ESTRO lecture: “How to bring QUANTEC into the 21° century ?» Turin 2016

n ≈ volume effect

D max

EUD