SBRT 2016

Prognostic factors related to survival after SBRT for mCRC

Covariate

Categories (n)

Median OS years (95 % CI) 2.5 (2.1 – 2.8) 1.2 (0.3- 1.9) 3.0 (2.4-3.6) 3.5 (2.8-4.2) 3.2 (2.6-3.8) 2.9 (2.6-3.6) 2.8 (2.5 – 3.4 ) 1.9 (1.5 – 2.1) 2.8 (2.3 – 3.4) 2.0 (1.8 – 2.5) 3.4 (2.3 – 5.1 ) 2.1 ( 1.9– 2.6) 2.6 (2.0 – 3.2) 2.1 (1.3 – 2.5) 2.6 (2.0- 2.8) 2.1 (1.9- 2.8) 2.5 (2.0 – 3.3) 2.3 (1.8 – 2.7)

HR

P- value

0-1 (187) 2-3 (14)

Performance status

2.54

<0.01

Males (136) Females (65)

Gender

0.65

0.03

<71 (101) >72 (100)

Age

1.10

0.38

≤ 30 mm (102) >30 mm (98)

Size of largest metastases

1.67

<0.01

1 metastasis (86) 2-6 metastases (115)

Number of metastases

1.49

0.02

Lung (30) Liver, other (171)

Treatment site

1.74

0.03

Yes (132) No (69) Yes (98) No (103)

Prior chemotherapy

1.44

0.03

Prior local therapy

1.16

0.39

Metachronous (70) Synchronous (131)

Timing of metastasis

1.14

0.48

MM Fode et al. Radiother Oncol 2015; 114(2):155