SBRT 2016

Is this „ EXCESSIVE TOXCITY “ really unexpected after RT with EXCESSIVE DOSES ? Risk adapted fractionation

Increased toxicity

No increased toxicity

3 x 12 Gy 6 x 6 Gy 8 x 7.5 Gy 4 x 12.5 Gy

3 x 20 / 22 Gy

Timmerman 2008

Joyner 2006

3-4 x 10-20 Gy

Senan 2007

Song 2009

Chang 2008

8 x 6 Gy

Guckenberger 2009

10 x 3-5 Gy

Milano 2009

5 x 10 Gy

Oshiro 2010

M Guckenberger - SBRT stage I NSCLC - HICARE 2015

21

/