SBRT2015

A short history of intracranial SRS

• 1908: !

Robert Henry Clarke and Victory Horsley: Stereotactic technique based on the reproducibility of the relationships between landmarks on the skull (external auditory canals, midline) and anatomical structures within the brain Lars Leksell: Experiments with 250 kV rotating X-ray source (1951) and stereotactic proton therapy (1955) Lars Leksell: Gamma-knife radiosurgery using 60 Co-sources for treatment of functional disorders

• 1950s: !

• 1967: !

• 1980s: !

Oswaldo Betti and Frederico Colombo: CT-localization and linac-based SRS

Betti et al.