SBRT2015

Re-irradiation for spinal metastases

Spinal cord tolerance – reirradiation: Animal studies

„Optimistic“ model

56 Rhesus monkeys, SFD 2.2Gy to 44Gy Reirradiation − 57.2Gy after 1 and 2 years − 66Gy after 2 and 3 years  4 / 45 animals developed RMP

Ang IJROBP 2001

„Pessimistic“ model

Optimistic model:  Recovery of 76%, 85% and 101% after 1, 2 and 3 years

Conservative model:  Recovery of 61%

SBRT for re-irradiation

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