SBRT2015

Is conventional radiotherapy inferior?

Randomised SPACE trial of conventional radiotherapy (CFRT) vs SABR (NCT019207)

Similar local failure rates ( 11% SABR v s 13% C F R T ) , r e g i o n a l recurrences (7% vs 8%, distant metastases (24% vs 23%) F e w e r c a s e s o f pneumonitis (16 vs 34%) and esophagitis (9 vs 32%) seen in SABR arm. Any G3-5 toxicity seen in 16 versus 18%

Study arms

SABR: 66 Gy in 3 fractions (to isocenter) CFRT: 70 Gy in 35 fractions

Primary End- point

Freedom from tumor progression at 36 months

Secondary end- points

OS at 36 months Toxicity, QoL

Total enrolled

102 patients (completed)

Nyman J, ESTRO 2014