Target Volume Determination 2015

Accuracy for lymph node metastases

Dynamic, contrast-enhanced MRI • Description of signal time curve • Pharmacokinetic 2-compartmental model

50 : 50

Possible remedies

Prostate carcinoma

Benign

hyperplasia

High-resolution Contrast MRI

Spectroscopy

MRS in prostate cancer

Ci

1

• Metabolites: – Choline (Cho) = Proliferation marker – Citrate (Ci), produced by prostatic cell = specific marker for vital glandular tissue – BPH: Citrate moderately decreased – Carcinoma: Citrate decreased, choline increased

• Grading/Characterization: MR Spectroscopy

Cho Cr

Lip

2

Benign hyperplasia

Ci

1

Ci

2

Cho

Cho

Cr

Ci

Cr

Cho

Lipids

Lip

Cr

δ [ppm] 4.0 3.0 2.0 1.0 0.0

4.0 3.0 2.0 1.0 0.0

δ [ppm]

Normal

Carcinoma

Carcinoma