Target Volume Determination 2015

Registration accuracy

Impact on margins?

Examples for registration uncertainties:

~ 0.5 mm for cranial CT-CBCT registration (Sykes et al.,PMB 2009) ≤ 2 mm for cranial CT-MR registration (Ulin et al., IJROBP 2010) ≥ 2 mm for CT-MR registration for rectal cancer (Dean et al., BJR 2012) ~ 2 mm for CT - MR registration for prostate (Nyholm et al., Radiat. Onc. 2009)

~ 5-7 mm for DIR

(Yeo et al., Med. Phys 2013)