Target Volume Determination 2015

First page Previous page 311 Next page Last page

StefanDelorme Division ofRadiology

Outline

Response: Tumor cells

Response: Tumor stroma

21.05.14 |

• Types of breast cancer • Imaging methods and features • Mammography • Ultrasound • CT • MRI • T stages • Nodal drainage and N Stages • Treated breast cancer

• Apoptosis

• Regression of cellular components – Lack of stimulation by tumor cells – Very delayed • Often persistence of fibrous components • Regression of vasculature – Lack of angiogenic stimulation – Direct treatment effects on vessels » Radiation » Anti-angiogenic treatment etc. » Chemotherapy

– Early (hours to days) – Single-cell pattern – No inflammatory reaction – Phagocytosis by neighbor cells

• Necrosis – Delayed (next mitosis, possibly after several cycles) – Grouped cell pattern – Inflammation – Phagocytosis by macrophages

StefanDelorme Division ofRadiology

Breast cancer: Possible response patterns

Microcalcifications

US: Partial response

21.05.14 |

Before chemotherapy

After chemotherapy

Made with FlippingBook