Target Volume Determination 2015

What are results of elective neck irradiation?

Isolated regional failure after IMRT

Isolated regional failure – lymph node relapse in cN0/pN+ after elective neck irradiation.

Median follow-up (year)

Chemo, n (%) 68 (45) 54 (54) 92 (32) 130 (77)

Elective neck D (Gy)

Isolated regional relapse

n

Study

Yao 2005

150

50-60 50-54 56-66

2%

1.5 2.7 2.3 2.9

Schoenfeld 2008 100

2% at 3 years 3% at 2 years

Duprez 2011

285 167

Yossi 2015

50

4.2%

<5%

≥50 Gy

Swallowing disturbances

De-intensification of elective neck irradiation

Yao et al. IJROBP 2005;6:101-8. Shoenfeld et al. IJROBP 2008;71;377-85. Duprez et al. IJROBP 2011; 79:450-8. Yossi et al. Cancer Radiother 2015; 19:73-81.