Target Volume Determination 2015

Do we need adaptive radiotherapy?

Adaptive IMRT

Trigged

Planned Biologic n = 21 11 (52%) 10 (48%)

End-point/measurement

Anatomic n = 51 22 (43%) 29 (57%)

Dose n =22

Tumor site: oropharynx Other Median follow-up (month) 2-year local control 2-year regional control 2-year locoregional control Topography of locoregional recurrence

22 (100%) -

30

31

25

- -

100%

95% 93%

95%

78%

-

-

GTV

CTV

4 high-dose PTV

Not reported

2 GTV (PET) 1 Elective neck

PTV

Chen at al. Head Neck 2014;83:986-93. Schwartz et al. IJROBP 2012;83:986-93. Madani et al. Radiother Oncol 2011;80:1045-55.