Upper GI 2016

ü Does dose impact long term outcome?

• RTOG 85-01 – 1999 • RTOG 85-01 – 1999 • RTOG 85-01 – 1999 • RTOG 85-01 - 1999

Phase III Trial RT (64Gy) vs RTCT (50Gy)

T1-3 N0-1M0

Low third: n.a. Adeno 21.4%

129 pts

SVV Benefit (RTCT vs RT Alone)

• INT 0123 – 2002 • INT 0123 – 2002 • INT 0123 – 2002 • INT 0123 - 2002

Phase III Trial RTCT (50Gy) vs RTCT (65Gy)

T1-T4 N0-1M0

Low third: n.a. Hystotype: n.a.

218 pts

NO SVV Benefit

Cooper et al ; - JAMA – 1999 Minsky et al; JCO 2002