Upper GI 2016

Are there differences between CT backbones?

mOS (months)

Study

Histol

Intent

Arms

Drugs

N pCR

2-yr OS

RCT (50Gy)

5FU/DDP

NA

8.9

38%

Herskovic 1992

20%SCC 80%ADC

definitive

129

50% (p<0.001)

RT (64Gy)

-

NA

12.5

RCT (18.5Gy split dose preop

DDP

143

26%

18.6

-

Bosset 1996

SCC

preop

surg alone

-

139

-

18.6

-

RCT (40Gy) preop

5FU/DDP

58

25%

16

37

Walsh 1996

ADC

preop

11 (p=0.001)

26 (p=0.01)

surg alone

-

55

-

inductionCT- RCT-Surgery

5FU/oxaliplat in

55

26%

46

-

Ajani 2013

97%ADC 3%SCC

preop

5FU/oxaliplat in

13% (NS)

RCT-surgery

54

43

-

RCT

cape/DDP

129

-

25.4

-

Crosby 2013

26%ADC 71%SCC

definitive

cape/DDP + cetux

22.1 (p=0.035)

RCT+cetuximab

129

-

-

RCT

FOLFOX

134

-

20.2

-

Conroy 2014

85%ADC 15%SCC

definitive

17.5 (p=0.7)

RCT

5FU/DDP

133

-

-

RCTpreop

CBDCA/taxol

178

29%

49.4

-

Van Hagen 2012

75%ADC 25%SCC

preop

24.0 (p=0.003)

surgery

-

188

-

-