Upper GI 2016
mOS (months)
Study
Histol
Intent
Arms
Drugs
N pCR
2-yr OS
5FU/DDP
NA
8.9
38%
RCT (50Gy)
Herskovic 1992
20%SCC 80%ADC
definitive
129
50% (p<0.001)
RT (64Gy)
-
NA
12.5
RCT (18.5Gy split dose preop
DDP
143
26%
18.6
-
Bosset 1996
SCC
preop
surg alone
-
139
-
18.6
-
RCT (40Gy) preop
5FU/DDP
58
25%
16
37
Walsh 1996
ADC
preop
11 (p=0.001)
26 (p=0.01)
surg alone
-
55
-
inductionCT- RCT-Surgery
5FU/oxaliplat in
55
26%
46
-
97%ADC 3%SCC
Ajani 2013
preop
5FU/oxaliplat in
13% (NS)
RCT-surgery
54
43
-
75%ADC 25%SCC
inductionCT- RCT-surg
Ilson 2012
preop
DDP/CPT11
55
16%
32
-
RCT
cape/DDP
129
-
25.4
-
26%ADC 71%SCC
Crosby 2013
definitive
cape/DDP + cetux
22.1 (p=0.035)
RCT+cetuximab
129
-
-
RCT
FOLFOX
134
-
20.2
-
Conroy 2014
85%ADC 15%SCC
definitive
17.5 (p=0.7)
RCT
5FU/DDP
133
-
-
RCTpreop
CBDCA/taxol
178
29%
49.4
-
Van Hagen 2012
75%ADC 25%SCC
preop
24.0 (p=0.003)
surgery
-
188
-
-
Made with FlippingBook