Upper GI 2016

DDP 60 mg/m 2 (D1) & capecitabine 625 mg/m 2 2*(D1-21) cycles 3 and 4 with RT (50 Gy/25 fractions) +/- weekly cetuximab

grade III-IV non-hematol tox (%)

mOS (months)

Arm

RCT

25.4

63

* including 3 treatment- related deaths

22.1 (p=0.035)

79* (p=0.004)

RCT+cetux

19% no RT in cetux arm (vs 8%)

Crosby et al Lancet Oncol 2013