Upper GI 2017

In this manuscript, a multidisciplinary panel proposes a methodological framework—the DESIGN guidelines —to standardize the clinical design of biomarker identification studies and to develop future research in this pivotal field

Design of biomarker identification studies using sequential samples from patients treated with systemic therapies : a. Baseline samples are obtained from all patients treated with a particular drug b. Sequential samples are obtained whenever a clinically relevant event (i.e., response, progression or marked toxicity) is observed

03/28/2017