Upper GI 2017

Neoscope Study – Trial Design

OxCapRT Arm : Oxaliplatin 130mg/m 2 Day1 + Capecitabine 625mg/m 2 bd Day 1- 21 (2 cycles) CRT: Oxal 85mg/m 2 Days 1, 15, 29 + Cape 625mg/m 2 bd Mon-Fri

Cape

Cape Cape

Cape Cape Cape

RT

Restaging CT/PET-CT Surgery (6-8 weeks post CRT) Follow up: 6 weeks, 6 & 12 months

45 Gy in 25 fractions

R

Cape

RT

45 Gy in 25 fractions

CarPacRT Arm : Oxaliplatin 130mg/m 2 Day 1 + Capecitabine 625mg/m 2 bd Day 1- 21 (2 cycles) CRT: Paclitaxel 50mg/m 2 & Carboplatin AUC 2 Days 1,8,15,22,29;

Oxaliplatin Carboplatin/Paclitaxel

Mukherjee S et al. ASCO-GI 2016

© Universitätsmedizin Leipzig: University Cancer Center Leipzig (UCCL), Prof. Dr. F. Lordick