paediatrics Brussels 17

High-dose chemotherapy (HDT) with busulfan/melphalan (Bu- Mel) may yield benefits for patients suffering from metastasized Ewing tumors compared with conventional chemotherapy

In late 2003, there was an alert concerning severe complications after BuMel HDT and irradiation of the spinal cord

Subsequently an amendment with a restriction of the radiation dose to the spinal cord of 30 Gray (Gy) after BuMel HDT and a warning regarding radiotherapy to central axial sites following BuMel HDT was established within the study protocol

In 2005, two reports from France described severe gut toxicity after BuMel HDT and high dose radiotherapy in the pelvis

Absence of severe toxicity problems in Germany