paediatrics Brussels 17

-SJCRH Data base including 266 survivors of Ewing's sarcoma: 16 second malignancies (6.0%) (median follow-up 9.5 years) - Median latency to the diagnosis of the second malignancy = 7.6 years (range, 3.5 to 25.7). - The cumulative incidence rate of secondary sarcoma was radiation dose-dependent (P = .002): • no secondary sarcomas in children with Ewing’s sarcoma who received dose <48 Gy. • the absolute risk of developing a secondary sarcoma after doses of 48–59.99 Gy was 24.9 cases/10,000 person-years; for doses of 60 Gy, it was 131 cases/10,000 person-years

Second malignancies after Ewing's sarcoma: radiation dose-dependency of secondary sarcomas. Kuttesch et al, J Clin Oncol, 1996