paediatrics Brussels 17

Summary and conclusions

✓ ES are the second most frequent primary bone cancer, affecting primarily patients in the second and third decades of life

✓ Patients presenting with localized disease have an approximately two thirds chance of being cured

✓ Those whose disease is initially systemic have a much worse outcome (30-40% EFS rate with isolated pulmonary mets, less than 20% chance of cure with bone or bone marrow involvement)

✓ No chance of cure in relapsing patients

✓ New therapeutic approaches required to cure refractory diseases and/or to reduce late effects