paediatrics Brussels 17

Wilms Tumor Stage I, Favorable Histology

NWTS-1

• Radiotherapy not necessary for Group 1 Wilms’ tumor < 2 years of age • There was a benefit for radiotherapy for Group 1 Wilms’ tumor > 2 years of age (2 yr DFS: 77% vs. 58%, p = 0.04). These pts were treated with Regimen A (AMD alone) NWTS-2 • Radiotherapy not used in Group I patients. VCR was added to regimen. Randomization was 6 mos vs. 15 mos. Of AMD + VCR. 3- yr RFS was 89% and 84% respectively

D'Angio GJ et al. Cancer 1976, D'Angio et al. Cancer 1981