paediatrics Brussels 17

Current COG Guidelines

Stage

Chemotherapy

Radiotherapy

Stage I, FH, age < 2 years with tumor and kidney weight < 550 grams

None

None

Stage I and II, FH with no LOH 1p and 16q

VCR and AMD (Regimen EE4A)

None

Stage I and II, FH with LOH at 1p and 16q

VCR, AMD and DOX (regimen DD4A) VCR, AMD and DOX (Regimen DD4A) VCR, AMD, DOX, CPM, VP16 (Regimen M)

None

Stage III, FH with no LOH at 1p and 16q

Abdominal/Flank RT

Stage III, FH with LOH at 1p and 16q

Abdominal/Flank RT

Stage IV, FH with no LOH at 1p and 16q

VCR, AMD and DOX (Regimen DD4A)

Abdominal/Flank RT if Local Stage III Lung XRT if Lung Mets not CR Abdominal/Flank RT if Local Stage III Lung XRT if Lung Mets

Stage IV, FH with LOH at 1p and 16q

VCR, AMD, DOX, CPM, VP-16 (Regimen M)